Transcatheter Aortic Valve Insertion – TAVI – is a technique involving the implantation of an artificial valve into a narrowed aortic valve without the need to stop the heart. There are two variants of this procedure. In the first, the artificial valve is...
New and emerging technologies for breast cancer detection
A comprehensive evaluation of the BreastScreen Australia Program has been conducted, under the direction of the Australian Health Ministers Advisory Council (AHMAC) and managed by the Department of Health and Ageing. To inform this evaluation, the Department of Health...
Insulin pump therapy for type 1 diabetes
The Alberta Health and Wellness’ Executive Committee accepted the Alberta Health Technology Decision Program’s Advisory Committee’s recommendation to undertake a STE analysis of insulin delivery systems. The purpose of this report is to address the following...
Core HTA on MSCT Coronary Angiography
The EUnetHTA project aims at facilitating HTA information sharing within Europe. In order to achieve this, the development of a standardised structure for the conduction and reporting of HTAs, a HTA Core Model, was considered essential. Work Package (WP) 4 of the...
Core HTA on Drug Eluting Stents
This report is an HTA on drug eluting stents. It is an application of the HTA Core Model for medical and surgical interventions and hence called a "Core HTA". The aim is to test the model and provide feedback that will be adjusted based on the experiment. Besides the...
Mitral Valve Clip for Treatment of Mitral Regurgitation: An Evidence-Based Analysis
Many of the 500,000 North American patients with chronic mitral regurgitation may be poor candidates for mitral valve surgery. The objective of this study was to investigate the comparative effectiveness, harms, and cost-effectiveness of percutaneous mitral valve...
Colon Capsule Endoscopy for the Detection of Colorectal Polyps: An Evidence-Based Analysis
Colorectal cancer, a leading cause of mortality and morbidity in Ontario, can be prevented through early diagnosis and removal of precancerous polyps. Colon capsule endoscopy is a relatively new, minimally invasive test for detecting colorectal polyps. The objectives...
Retinal Prosthesis System for Advanced Retinitis Pigmentosa: A Health Technology Assessment Update
Retinitis pigmentosa is an eye disease people are born with. People who have it slowly lose their vision. The Argus II retinal implant is the only treatment approved by Health Canada for retinitis pigmentosa. A device is implanted in a patient’s eye, and it...
The effectiveness and cost-effectiveness of dual-chamber pacemakers compared with single-chamber pacemakers for bradycardia due to atrioventricular block or sick sinus syndrome: systematic review and economic evaluation
The objective of the assessment was to estimate the effectiveness and cost-effectiveness of dualchamber pacemakers versus single-chamber atrial or single-chamber ventricular pacemakers in the treatment of bradycardia due to sick sinus syndrome...
Comparative effectiveness of MRI in breast cancer (COMICE) trial: a randomised controlled trial
MRI might improve diagnosis of breast cancer, reducing rates of reoperation. We assessed the clinical efficacy of contrast-enhanced MRI in women with primary breast cancer.We undertook an open, parallel group trial in 45 UK centres, with 1623 women aged 18 years or...
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