The aim of this project was to examine the effectiveness and safety of mechanical thrombectomy plus standard of care versus standard of care alone, in adults aged 18 years or older with acute ischaemic stroke in the anterior and/or posterior region. CE-marked...
Percutaneous heart valve implantation in congenital and degenerative valve disease. A rapid Health Technology Assessment.
This Health Technology Assessment report summarises current evidence supporting the use of percutaneous heart valves in degenerative aortic valve and congenital pulmonary outflow tract disease, as compared to conservative medical therapy or traditional surgical valve...
Interspinous implants and pedicle screws for dynamic stabilization of lumbar spine: Rapid assessment
This rapid assessment concerns the clinical effectiveness and the efficiency of innovative surgical technologies proposed for the treatment of degenerative spinal conditions: interspinous spacers and pedicle screw systems. These techniques are presented as...
Implantable devices for closure of patent foramen ovale (PFO) in adults
Percutaneous closure of patent foreman ovale (PFO) is one of the treatment options for patients with PFO suffering from transient ischemic attacks (TIA), cryptogenic stroke or persistent migraine. At time of writing, none of the several CE marked PFO closure devices...
Ultrasonic energy devices for surgery
Ultrasonic energy devices for surgery were developed in the early 1990s and are now available for both open and endoscopic surgical procedures. The operating principles of the ultrasonic energy devices for surgery are mainly related to the high-frequency...
Implantable cardiac resynchronization therapy and defibrillator (CRT-D) in patient with heart failure
In Italy, cardiovascular disease is a leading cause of mortality, morbidity, and disability. Among all cardiovascular diseases, a prominent role is played by heart failure (HF), with 600,000 people suffering from heart failure. It is estimated that the frequency of...
High-intensity focused ultrasound for the treatment of prostate cancer
Prostate cancer (PCa) is the most common non-skin cancer in men in Europe. In early stage, prostate cancer is localised and organ-confined. Depend-ing on the risk of progression, the cancerous lesion increases in volume and produces more PSA over time. Localised...
Balloon Eustachian tuboplasty for the treatment of Eustachian tube dysfunction
The aim of this rapid assessment is to summarise the information on the relative effectiveness and safety of balloon Eustachian tuboplasty (BET) for the treatment of Eustachian tube dysfunction (ETD) in a population aged over 12 years. The comparators included...
Biodegradable stents for the treatment of refractory or recurrent benign oesophageal stenosis
Benign oesophageal stenosis (BOS) is a condition in which the normal oesophageal lumen is constricted and the normal passage of swallowed food from the upper oesophagus to the stom-ach is impeded. BOS can be caused by a wide range of disorders such as peptic steno-ses...
Duodenal-jejunal bypass sleeve for the treatment of obesity with or without Type 2 Diabetes
This assessment addresses two subpopulations of interest: 1) adult obese patients (grade III obesity/BMI ≥40 or grade II obesity/BMI 35.0–39.9 with comorbidities) 2) patients with Type 2 DM and obesity ≥ grade I. The DJBS is a 60 cm long impermeable...
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