{"id":225431,"date":"2026-02-25T11:56:21","date_gmt":"2026-02-25T08:56:21","guid":{"rendered":"https:\/\/new-inbit.dev-praxis.gr\/?post_type=hta_library&#038;p=225431"},"modified":"2026-02-25T11:56:22","modified_gmt":"2026-02-25T08:56:22","slug":"comparative-effectiveness-of-mri-in-breast-cancer-comice-trial-a-randomised-controlled-trial","status":"publish","type":"hta_library","link":"https:\/\/www.inbit.gr\/el\/hta_library\/comparative-effectiveness-of-mri-in-breast-cancer-comice-trial-a-randomised-controlled-trial\/","title":{"rendered":"Comparative effectiveness of MRI in breast cancer (COMICE) trial: a randomised controlled trial"},"content":{"rendered":"\n<p>MRI might improve diagnosis of breast cancer, reducing rates of reoperation. We assessed the clinical\u00a0efficacy of contrast-enhanced MRI in women with primary breast cancer.We undertook an open, parallel group trial in 45 UK centres, with 1623 women aged 18 years or older withbiopsy-proven primary breast cancer who were scheduled for wide local excision after triple assessment. Patients\u00a0were randomly assigned to receive either MRI (n=816) or no further imaging (807), with use of a minimisation\u00a0algorithm incorporating a random element. The primary endpoint was the proportion of patients undergoing a repeat\u00a0operation or further mastectomy within 6 months of random assignment, or a pathologically avoidable mastectomy\u00a0at initial operation. Analysis was by intention to treat.<\/p>\n","protected":false},"featured_media":0,"template":"","categories":[19],"tags":[32,84],"class_list":["post-225431","hta_library","type-hta_library","status-publish","hentry","category-other","tag-cancer","tag-mri"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.inbit.gr\/el\/wp-json\/wp\/v2\/hta_library\/225431","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.inbit.gr\/el\/wp-json\/wp\/v2\/hta_library"}],"about":[{"href":"https:\/\/www.inbit.gr\/el\/wp-json\/wp\/v2\/types\/hta_library"}],"wp:attachment":[{"href":"https:\/\/www.inbit.gr\/el\/wp-json\/wp\/v2\/media?parent=225431"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.inbit.gr\/el\/wp-json\/wp\/v2\/categories?post=225431"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.inbit.gr\/el\/wp-json\/wp\/v2\/tags?post=225431"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}