In patients where coronary artery disease (CAD) is suspected – either because of the presence of risk factors for CAD or because of symptoms that may represent manifestations of CAD (e.g., chest pain) – the standard electrocardiogram (ECG) is one of the most commonly performed tests. The ECG is nearly universally available, noninvasive, easy to perform, relatively inexpensive, and can usually be completed in less than 10 minutes. However, a resting ECG has limited sensitivity for detecting CAD. New devices that seek to improve ECG capabilities have been proposed – specifically, devices that are potentially capable of detecting significant CAD or myocardial ischemia.